The Science behind LeLi
How LeLi Heals Insulin Resistance and Type 2 Diabetes
LeLi
TREATMENT - the GOAL
Lipolysis
This knowledge is essential for addressing insulin resistance and type 2 diabetes. Here's how the body manages energy storage and utilization across different stages:
At LeLi Treatment, we are dedicated to delivering cutting-edge, science-based solutions to transform how diabetes is managed. Our approach is grounded in the latest research on glucose metabolism, insulin resistance, and sustainable health strategies, ensuring that every individual can achieve measurable improvements in their metabolic health.
Why Insulin Resistance is the Root Cause
Insulin resistance — a condition in which the body’s cells become less responsive to insulin—is the underlying factor in many cases of type 2 diabetes and prediabetes. Left unchecked, insulin resistance leads to elevated blood sugar levels, increased fat storage, and systemic inflammation. Research shows that tackling insulin resistance directly can:
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Stabilize Blood Sugar: Minimize spikes that stress the body and lead to energy crashes.
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Reduce Inflammation: Chronic high glucose levels contribute to inflammation, which is linked to cardiovascular disease, neuropathy, and other complications.
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Enhance Longevity: Studies indicate that reversing insulin resistance can lower the risk of long-term health conditions like Alzheimer's, fatty liver disease, and certain cancers.
The Science Supporting LeLi
LeLi Treatment combines personalized nutrition, lifestyle interventions, and evidence-based strategies to address insulin resistance. Here’s how our program aligns with the latest findings in metabolic health science:
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Balancing Glucose Spikes: Research confirms that avoiding glucose spikes not only reduces inflammation but also slows cellular aging caused by glycation.
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Restoring Insulin Sensitivity: A tailored combination of dietary changes and physical activity has been shown to re-sensitize cells to insulin, making glucose uptake more efficient.
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Sustainable Metabolic Improvements: LeLi helps patients achieve long-term results by addressing underlying metabolic dysfunction rather than just treating symptoms.
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The Global Importance of Managing Blood Sugar
Reducing sugar intake and managing glucose levels are priorities recognized by major health organizations:
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The World Health Organization (WHO) recommends limiting free sugar intake to less than 10% of total daily calories to combat obesity and chronic diseases.
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The United Nations Food and Agriculture Organization (FAO) emphasizes reducing sugar to prevent non-communicable diseases like diabetes and cardiovascular conditions.
LeLi Treatment takes these principles further by empowering individuals to not just lower their sugar intake but also to understand how to mitigate the impact of carbohydrates on their blood sugar levels through scientifically proven methods.
Benefits Beyond Diabetes
Even individuals without diabetes can benefit from managing glucose spikes and improving insulin sensitivity. Research shows that balancing glucose levels can:
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Reduce cravings and fatigue.
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Improve mental clarity and reduce brain fog.
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Enhance hormonal health, fertility, and skin quality.
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Alleviate menopause symptoms and improve sleep.
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Lower risks of chronic diseases, including heart disease and Alzheimer's.
What Happens During a Glucose Spike ?
1. Mitochondria Overload and Oxidative Stress
When glucose spikes, mitochondria — the energy powerhouses of our cells — become overwhelmed, producing harmful free radicals. This leads to oxidative stress and inflammation, which damage cells, mutate DNA, and are linked to a variety of chronic diseases. Notably, spikes from sweet foods cause more harm than starchy ones, with inflammation being a driving factor behind three out of five deaths globally.
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Biplab Giri et al., "Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: an update on glucose toxicity,” Biomedicine & pharmacotherapy, no. 107 (2018): 306-328.
https://www.sciencedirect.com/science/article/pii/S0753332218322406#fig0005
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Martin Picard et al., "Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids," Nature Reviews Endocrinology 10, no. 5 (2014): 303-310.
https://www.uclahealth.org/reversibility-network/workfiles/resources/publications/picard-endocrinol.pdf
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Robert H Lustig, "Fructose: it's “alcohol without the buzz”," Advances in nutrition 4, no. 2 (2013): 226-235.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649103
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Roma Pahwa et al., "Chronic inflammation," (2018).
https://www.ncbi.nlm.nih.gov/books/NBK493173
These spikes harm the body whether they occur in people with or without diabetes, making glucose management crucial for everyone.
2. Accelerated Aging Through Glycation
Every glucose spike triggers glycation—a process where sugar molecules attach to proteins or fats in the body, leading to cellular aging. Glycation is linked to age-related health issues such as cataracts, Alzheimer’s, and vascular damage. Reducing spikes helps slow down this process, promoting healthier aging.
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Alejandro Gugliucci, "Formation of fructose-mediated advanced glycation end products and their roles in metabolic and inflammatory diseases," Advances in nutrition 8, no. 1 (2017): 54-62,.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984
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Ashok Katta et al., "Glycation of lens crystalline protein in the pathogenesis of various forms of cataract," Biomedical research 20, no. 2 (2009): 119-121.
https://www.researchgate.net/profile/Ashok-Katta-3/publication/233419577_Glycation_of_lens_crystalline_protein_in_the_pathogenesis_of_various_forms_of_cataract/links/02e7e531342066c955000000/Glycation-of-lens-crystalline-protein-in-the-pathogenesis-of-various-forms-of-cataract.pdf
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Chan-Sik Kim et al., "The role of glycation in the pathogenesis of aging and its prevention through herbal products and physical exercise," Journal of exercise nutrition & biochemistry 21, no. 3 (2017): 55-61.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643203
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Georgia Soldatos et al., "Advanced glycation end products and vascular structure and function," Current hypertension reports 8, no. 6 (2006): 472-478.
https://pubmed.ncbi.nlm.nih.gov/17087858
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Masamitsu Ichihashi et al., "Glycation stress and photo-aging in skin," Anti-aging medicine 8, no. 3 (2011): 23-29.
https://www.jstage.jst.go.jp/article/jaam/8/3/8_3_23/_article/-char/ja
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Masayoshi Takeuchi et al., "Involvement of advanced glycation end-products (AGEs) in Alzheimer's disease," Current Alzheimer research 1, no. 1 (2004): 39-46.
https://pubmed.ncbi.nlm.nih.gov/15975084
3. Fat Storage and the Role of Insulin
During a glucose spike, insulin is released to help store excess glucose in the liver, muscles, and fat cells—contributing to weight gain. Sweet spikes, in particular, often involve fructose, which is processed differently than glucose and can lead to fatty liver and other metabolic disturbances.
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Bettina Geidl-Flueck et al., "Fructose-and sucrose-but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial," Journal of hepatology 75, no. 1 (2021): 46-54.
https://www.journal-of-hepatology.eu/article/S0168-8278(21)00161-6/fulltext
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João Silva et al., "Determining contributions of exogenous glucose and fructose to de novo fatty acid and glycerol synthesis in liver and adipose tissue." Metabolic engineering 56 (2019): 69-76.
https://www.sciencedirect.com/science/article/pii/S109671761930196X
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Lubert Stryer, "Fatty acid metabolism,” In: Biochemistry (Fourth ed.) (New York: W.H. Freeman and Company, 1995), pp. 603–628.
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Samir Softic et al., "Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease," Digestive diseases and sciences 61, no. 5 (2016): 1282-1293.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838515
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Stryer L (1995). Biochemistry (Fourth ed.). New York: W.H. Freeman and Company. pp. 773–74.
Each glucose spike not only impacts immediate energy levels but also has long-term repercussions for metabolic, cardiovascular, and cellular health. Maintaining balanced glucose levels is essential to prevent these adverse effects.
Supporting Evidence for LeLi's Approach
Numerous studies underpin the effectiveness of addressing glucose spikes and insulin resistance:
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In healthy individuals, fasting glucose levels below 85 mg/dL are associated with lower risks of cardiovascular disease and improved longevity.
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Longitudinal studies show that even within the normal range, lower glucose variability correlates with better metabolic outcomes.
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A groundbreaking study demonstrated that post-meal physical activity could significantly reduce glucose spikes, a core principle of the LeLi program.
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Why Balanced Glucose Levels Matter — Even Without Diabetes
It’s a common belief that maintaining glucose levels within the “normal” range is sufficient for good health. However, research shows that even within the healthy fasting glucose range (commonly defined as under 100 mg/dL by the ADA), lower levels—ideally between 85-90 mg/dL—are linked to better overall health outcomes. This underscores the importance of managing glucose levels, even for individuals without diabetes.
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A long-term study tracking 2,000 men without diabetes over 22 years found that those with fasting blood glucose levels above 85 mg/dL faced a significantly higher risk of death from cardiovascular diseases compared to those with lower glucose levels. This underscores the importance of maintaining lower fasting glucose for long-term heart health. (Bjørnholt, JØRGEN V., et al., Diabetes Care, 1999: 45–49).
https://diabetesjournals.org/care/article/22/1/45/19692/Fasting-blood-glucose-an-underestimated-risk
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Research involving over 1 million healthy Korean adults revealed that the risk of cardiovascular problems was lowest when fasting glucose levels were around 90 mg/dL. Above this threshold, the risk of heart-related issues rose sharply for both men and women. This study highlights the importance of maintaining optimal glucose levels for heart health. (Park, Chanshin, et al., Diabetes Care, 2013: 1988–1993).
https://diabetesjournals.org/care/article/36/7/1988/33101/Fasting-Glucose-Level-and-the-Risk-of-Incident
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A notable study tracking 17,000 healthy participants over 11 years revealed that the risk of mortality increased with higher average glucose levels, even those considered below the threshold for diabetes. (Pfister, R., et al., Diabetologia, 2011: 2025–2032).
https://link.springer.com/article/10.1007/s00125-011-2162-0
Why Glucose Spikes Are Worse Than Steady Glucose Levels
Managing glucose variability is critical for both immediate well-being and long-term health. Research shows that spikes in blood sugar are more harmful to the body than maintaining a consistently elevated yet stable glucose level.
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Insights from leading experts highlight the role of glucose management in preventing chronic disease (Benjamin Bikman, 2020; Robert Lustig, 2021).
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Emerging “glucotypes” reveal distinct patterns of glucose instability and its impact on health. (Heather Hall et al., PLoS Biology, 2018).
https://pubmed.ncbi.nlm.nih.gov/30040822
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Most American adults fall short of achieving optimal metabolic health, partly due to poor glucose regulation. (Joana Araújo et al., Metabolic Syndrome and Related Disorders, 2019).
https://pubmed.ncbi.nlm.nih.gov/30484738
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Chronic glucose fluctuations can impair the body’s ability to regulate key hormones like glucagon. (Xi Chen et al., Metabolism, 2023).
https://www.sciencedirect.com/science/article/abs/pii/S0026049523001154
The problem lies in the variability: glucose spikes trigger oxidative stress and damage at the cellular level.
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Acute glucose fluctuations harm blood vessels more than consistently high glucose levels. (Antonio Ceriello et al., Diabetes, 2008).
https://diabetes.diabetesjournals.org/content/57/5/1349.short
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Glycemic variability is a key marker for diagnosing prediabetes and diabetes. (Giada Acciaroli et al., Journal of Diabetes Science and Technology, 2018).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761967
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Oxidative stress from spikes can be more damaging than sustained hyperglycemia. (Louis Monnier et al., JAMA, 2006).
https://jamanetwork.com/journals/jama/article-abstract/202670
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Short-term glucose spikes accelerate atherosclerosis development. (Michelle Flynn et al., Circulation Research, 2020).
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.120.316653
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High variability correlates with worse clinical outcomes. (Zheng Zhou et al., Cardiovascular Diabetology, 2020).
https://link.springer.com/article/10.1186/s12933-020-01085-6
Keeping glucose levels steady is essential to protect against these damaging effects.
What Is the Optimal Fasting Glucose Level?
While the American Diabetes Association (ADA) defines a fasting glucose level of <100 mg/dL as normal, research suggests that normal might not always mean optimal. Evidence points to fasting glucose levels below 85 mg/dL as being more closely associated with long-term health and reduced risk of disease. Additionally, minimizing glucose spikes remains a crucial part of glucose management.
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The ADA highlights <100 mg/dL as the benchmark for healthy fasting glucose. (American Diabetes Association, 2023).
https://www.diabetes.org/a1c/diagnosis
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Elevated fasting glucose—even within the normal range—has been linked to higher cardiovascular mortality risk. (Jørgen Bjørnholt et al., Diabetes Care, 1999).
https://care.diabetesjournals.org/content/22/1/45
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Risks for heart disease increase sharply above fasting glucose levels of ~90 mg/dL. (Chanshin Park et al., Diabetes Care, 2013).
https://care.diabetesjournals.org/content/36/7/1988
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Even in healthy individuals, continuous glucose monitoring shows significant fluctuations, emphasizing the importance of stability. (Guido Freckmann et al., Journal of Diabetes Science and Technology, 2007).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769652
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High-normal fasting glucose in children predicts prediabetes and type 2 diabetes in adulthood. (Quoc Manh Nguyen et al., JAMA Pediatrics, 2010).
https://jamanetwork.com/journals/jamapediatrics/fullarticle/382778
Striving for optimal fasting glucose levels and avoiding variability can support both immediate well-being and long-term health outcomes.
The BENEFITS of flattening the Glucose Levels
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